In pharmaceutical drug substance (DS) manufacturing, resin chromatography is a critical purification step. Preparation of chromatography resin slurries is essential for column packing and effective DS purification. Inconsistent slurries can lead to voids or channeling, compromising purification efficiency. Eberbach’s C6155 and C6145 large-capacity orbital shakers ensure homogeneous slurries for uniform resin beds, enhancing column performance.
The Eberbach C6155 and C6145 large-capacity orbital shakers are engineered for gentle, continuous mixing, ideal for resuspending viscous chromatography resins in large carboys in a short time. This efficient mixing achieves uniformity quickly, improving process reliability. No more manual shaking of large containers or carboys that can cause injury to a person. Unlike traditional stirred tanks, which may introduce shear forces and potential contamination, the orbital motion of these shakers ensures uniform mixing without intrusive impellers. This design minimizes cross-contamination, shear stress, air bubble formation, and channeling, leading to more efficient column packing and better purification outcomes.
Key features of the C6155 and C6145 include:
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Variable-speed control for tailored mixing protocols.
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Large load capacities, accommodating up to 500 lb loads.
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cGMP-compliant stainless steel construction suitable for cleanroom environments.
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Customizable platforms to fit various vessel types and sizes.
For facilities seeking to enhance resin slurry preparation, the Eberbach C6155 and C6145 orbital shakers offer a reliable, efficient, and safe solution. Contact Eberbach Corporation to learn more about their applications in chromatography resin resuspension.