Chromatography Resin Shakers

Automated, Repeatable Precision for Resin Preparation:

Streamline your chromatography workflows from start to finish with Eberbach’s heavy-duty chromatography resin shakers. Engineered for continuous operation with a reliable and robust design, these units provide an automated, repeatable process for resin resuspension and slurry preparation across research, quality control, pilot production, and full-scale manufacturing.

Key Operational Benefits Include:

• Ergonomic Safety: Significantly reduces human fatigue and minimizes the risk of injury associated with manual resin shaking.
  
• Contamination Control: Eliminates cross-contamination by shaking resin entirely within a closed container. There is no need to open vessels or insert external tools such as wands or paddles.
  
• Reduced Maintenance: Lowers cleaning costs and protects product integrity by completely preventing exposure.

Built for Your Process

Each shaker is custom-engineered to match your specific facility and process requirements, ensuring seamless integration into your existing laboratory or production environment.

Key Advantages and Features

• Heavy-Duty Robust Resuspension:
  • Built tough for demanding applications, expertly designed for reliable resin homogenization.
    
• Low-Shear Motion:
  • Gentle action safeguards resin integrity, preventing structural breakdown during processing.
• Contamination-Free Closed System:
  • Eliminates cross-contamination entirely and reduce biofilm formation.
• Rapid Processing:
  • Achieve complete resin resuspension in under 10 minutes, maximizing daily throughput.
• Direct Transfer Capabilities:
  • Seamlessly transition resin straight to your stirred tank or chromatography column with zero fuss.
• Minimal Maintenance:
  • Designed for low effort upkeep with minimal cleaning requirements to keep your operations moving.

Accessories/Options

• Advanced Controls Options:
  • Comprehensive HMI/PLC control packages featuring audio visual alarms, recipe functionalities, and remote diagnostics.
• Network Integration Options:
  • Secure user login controls, remote operation, and robust data extraction (tracking time, speed, batch ID, and date).
• Specialized Sensors:
  • Application specific sensor packages tailored to your exact operational requirements.
• Enhanced Safety:
  • Optional safety enclosures and physical guarding for maximum operator protection.
• Hazardous Location Rating Options:
  • Explosion proof configurations available for sensitive or high risk environments.
• Certifications and Labeling:
  • Optional UL 6010 (or equivalent) certifications, CE marking, specialized material surface finishes, and hazardous explosion proof labeling.
• Integrated Weighing:
  • Built-in load cell output options for precise measurement
• CFD Analysis:
  • Optional Computational Fluid Dynamics computer simulations to evaluate shear stress, blending time, and oxygen transfer rates

6140 Small Capacity Resin Shaker	6145 Medium Capacity Resin Shaker	6155 Heavy Duty Resin Shaker

Manual vs Shaker ROI Comparison

The Current Challenge and Limitations of Manual Resuspension

• Labor Intensity:
  • High physical demand on technicians for manual shaking/rolling
• Inconsistency:
  • High variability in resin slurry homogenization leads to poor column packing
• Safety Risks:
  • Risk of repetitive strain injuries (RSI) on technicians or fatigue-related accidents can potentially expose companies to workers’ compensation claims, regulatory scrutiny, and added costs
• Scalability:
  • Limited scalability bottlenecks

Solution: Eberbach Shaker Systems

• Uniformity:
  • Provides consistent, reproducible resin homogenization
• Efficiency:
  • Multi-carboy capacity allows for simultaneous resin homogenization
• Closed System Integration:
  • Reduced risk of contamination, bacterial growth, and DS exposure
• Documentation:
  •  Digital controls allow for electronic chain of custody logs, repeatable SOPs, and data extraction

Operational Comparison

Financial Impact & ROI Drivers: Where Does the Savings Come From?

• Labor Savings:
  • Reduction in FTE (Full-Time Equivalent) hours required for slurry prep. FTE is a unit of measurement used to standardize the workload of a person or a project. It represents the number of hours worked by one full-time employee during a specific period (usually a year).
• Reduction in Failed/Poor Column Pack:
  • Reduction in loss of Expensive Drug Substance
  • Reduction in loss of Expensive Resin
  • Reduction in loss of Labor
• Increased Throughput:
  • Faster turnaround for column packing increases overall suite availability.
• Mitigated Risk:
  • Reduction in worker compensation claims, workers taking off time due to injury, and quality deviations.

ROI Calculations and Equations

• Labor Rate: $45/hr per technician (1)
• Yearly Cycles: 150 per year (2)

Assumptions

• Assumption 1: Full burden labor rate is being estimated at $45/hr per technician
• Assumption 2: 150 cycles (column packs) per year (Customer Dependent)
• Assumption 3: Eberbach resin shakers roughly cost $150,000, but prices vary on process/facility requirements
• Assumption 4:  Labor hours required:
  • Assuming 4 hours required for one technician to manually resuspend (x8) 20L carboys per batch
  • Assuming 10 minutes for one technician to load/unload (x8) 20L carboys on Eberbach shaker
• Assumption 5: An estimated 10 failure events for manual resuspension and 1 for Eberbach shaker resuspension excluding loss of drug substance:
  • The metrics for manual resuspension are derived from the BioPlan Associates: 20th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production (2023). Section on “Batch Failure Rates and Trends.“
  • The metrics for shaker resuspension are derived from BioProcess International (2023-2024): Reports on “Single-Use Technologies and Automation” highlight that automated resuspension is the industry standard for achieving the +/- 1% slurry accuracy required for high-compression columns.
  • Failure events: incorrectly packed column, contaminated resin, loss of resin bead integrity, operator error, etc.
• Assumption 6: Average cost per failure at $26,000:
  • These metrics are derived from the BioPlan Associates 21st Annual Report (2024) and the Cytiva white paper “Cost and Impact of a Bioburden Incident” (2017/Updated 2023)

Strategic Benefits

• Compliance:
  • Electronic records with chain of custody capability can allow for easier audits.
• Cost:
  • Reduction of loss of DS, reduction of loss of resin, loss of labor, and slower/poor column packing results in improved drug substance batch costs.
• Injury Reduction:
  • Reduces risk of workers getting injured due to intense manual labor. Further, reduction in employee absenteeism, insurance costs, overtime costs, and employee turnover.
• Quality:
  • Improved HETP (Height Equivalent to a Theoretical Plate), poor column packing is a major cause of a high Height Equivalent to a Theoretical Plate (HETP)

Conclusion and Recommendation

• Summary:
  •  The transition to Eberbach shaker systems offers a clear path to improved process robustness and significant cost recovery. Eberbach shakers reduce operator injury and allows operators to focus their attention on other tasks
    
• Recommendation:
  • Eberbach offers a variety of shaker sizes to improve chromatography slurry prep processes that range from R&D, Quality Control, Pilot Scale, Small Scale Manufacturing, and Large-Scale Manufacturing.

Eberbach's C6155.021 Custom Heavy Duty Orbital Shaker

 

Wand vs Shaker ROI Comparison

The Current Challenge and Limitations of Wand Resuspension

• Variable Homogenization:
  • Slurry concentration varies between operators, leading to inconsistent column packing 
• Resin Damage:
  • Manual “poking” and scraping can shear expensive resin beads, creating fines 
• Contamination Risk:
  • Opening carboys to insert wands introduce environmental bioburden. Wands require regular cleaning, if the cleaning is not done correctly the wand can increase  contamination risk, cleaning has significant added costs as well
• Safety/Ergonomics:
  • Risk of shoulder and wrist repetitive strain injuries (RSI) as well as risk of fatigue-related accidents can potentially expose companies to workers’ compensation claims, regulatory scrutiny, and added costs 
• Loss of Resin:
  • Resin can spill out due to carboy size being too small for the wand to properly function

Solution: Eberbach Shaker Systems

• Uniformity:
  • Provides consistent, reproducible resin homogenization 
• Efficiency:
  • Multi-carboy capacity allows for simultaneous resin homogenization 
• Closed System Integration:
  • Reduced risk of contamination, bacterial growth, and DS exposure 
• Documentation:
  • Digital controls allow for electronic chain of custody logs, repeatable SOPs, and data extraction

Operational Comparison

Financial Impact & ROI Drivers: Where Does the Savings Come From?

• Labor Savings:
  • Reduction in FTE (Full-Time Equivalent) hours required for slurry prep. FTE is a unit of measurement used to standardize the workload of a person or a project. It represents the number of hours worked by one full-time employee during a specific period (usually a year). 
• Reduction in Failed/Poor Column Pack:
  • Reduction in loss of Expensive Drug Substance
  • Reduction in loss of Expensive Resin
  • Reduction in loss of Labor 
• Increased Throughput:
  • Faster turnaround for column packing increases overall suite availability 
• Mitigated Risk:
  • Reduction in worker compensation claims, workers taking off time due to injury, and quality deviations. 
• Elimination of Cleaning/Replacement:
  • Reduction in costs associated with cleaning of wand or wand replacement after each batch. 
    • ROI calculation below excludes wand cleaning and replacement costs as these are customer dependent

Solution: Eberbach Shaker Systems

• Uniformity:
  • Provides consistent, reproducible resin homogenization 
• Efficiency:
  • Multi-carboy capacity allows for simultaneous resin homogenization 
• Closed System Integration:
  • Reduced risk of contamination, bacterial growth, and DS exposure

ROI Calculations and Equations

• Labor Rate: $45/hr per technician (1)
• Yearly Cycles: 150 per year (2)
• This ROI excludes costs to clean or replace resin wands

Assumptions

• Assumption 1: Full burden labor rate is being estimated at $45/hr per technician
• Assumption 2: 150 cycles (column packs) per year (Customer Dependent)
• Assumption 3: Initial investment: Resin wand systems roughly cost $6,000 Eberbach resin shakers roughly cost $150,000, but prices vary on process/facility requirements
• Assumption 4: Labor hours required:
  • Assuming 2 hours required for one technician to wand resuspend (x8) 20L carboys per batch
  • Assuming 10 minutes for one technician to load/unload (x8) 20L carboys on Eberbach shaker
  • The metrics for wand time are derived from Cytiva Data File (28-9273-50 AB): Media Wand and Media Handling Unit. Specifically details the spray-and-suction mechanism and the associated time/labor savings. 
• Assumption 5: An estimated 10 failure events for manual resuspension and 1 for Eberbach shaker resuspension excluding loss of drug substance:
  • The metrics for wand resuspension are derived from the BioPlan Associates: 21st Annual Report and Survey of Biopharmaceutical Manufacturing.
  • The metrics for shaker resuspension are derived from BioProcess International (2023-2024): Reports on “Single-Use Technologies and Automation” highlight that automated resuspension is the industry standard for achieving the +/- 1% slurry accuracy required for high-compression columns.
  • Failure events: incorrectly packed column, contaminated resin, loss of resin bead integrity, operator error, etc. 
• Assumption 6: Average cost per failure at $26,000:
  • These metrics are derived from the BioPlan Associates 21st Annual Report (2024) and the Cytiva white paper “Cost and Impact of a Bioburden Incident” (2017/Updated 2023)

Strategic Benefits

• Compliance:
  • Electronic records with chain of custody capability can allow for easier audits. 
• Cost:
  • Reduction of loss of DS, reduction of loss of resin, loss of labor, and slower/poor column packing results in improved drug substance batch costs. 
• Injury Reduction:
  • Reduces risk of workers getting injured due to intense manual labor. Further, reduction in employee absenteeism, insurance costs, overtime costs, and employee turnover. 
• Quality:
  • Improved HETP (Height Equivalent to a Theoretical Plate), poor column packing is a major cause of a high Height Equivalent ta Theoretical Plate (HETP)

Conclusion and Recommendation

• Summary:
  • The transition to Eberbach shaker systems offers a clear path to improved process robustness and significant cost recovery. Eberbach shakers allow operators to focus their attention on other tasks. 
• Recommendation:
  • Eberbach offers a variety of shaker sizes to improve chromatography slurry prep processes that range from R&D, Quality Control, Pilot Scale, Small Scale Manufacturing, and Large-Scale Manufacturing.