Eberbach Corporation's Single-Use Mixers are impeller-free mixing systems that generate bulk fluid movement by moving the entire vessel using orbital, reciprocal, or rocking motions. They're used across upstream processing (media dissolution, dilution, blending, pH/osmolality adjustment), offline preparation (seed media and buffers, feed blending, cell bank resuspension), antifoam and process additive handling, and downstream processing (buffer prep, feed conditioning, viral inactivation, UF/DF prep, and final formulation/fill-finish). These platform come in different capacity sizes to handle most application needs, small, medium and large capacity — with options for integrated load cells, advanced machine controls, SCADA integration, specialized sensors, safety enclosures, hazardous-location ratings, and Eberbach offers CFD analysis and simulations.
Applications
Upstream Processing
• Dissolving dry powdered media
• Diluting concentrated liquid media
• Blending multiple media components
• Adjusting pH and osmolality
• Maintaining homogeneity during sterile filtration
• Preparing media for seed reactors and production reactors
Offline Preparation
Concentrated feeds are prepared separately and added during fed-batch culture.
These feeds include:
- Seed Media Preparation
- Seed Buffer Preparation and Solution Formulation
- Supplement and Feed Media Blending
- High-Density Cell Bank Thawing and Resuspension Pooling
Antifoam & Process Additives
- Dilution of concentrated antifoam
- Blending surfactants
- Preparing process additives
- Suspending additives that settle during hold
Downstream Processing
- Chromatography-buffer preparation
- Buffer dilution from concentrates
- Chromatography-feed conditioning:
- pH adjustment
- Conductivity adjustment
- Salt addition
- Dilution
- Addition of stabilizers
- Addition of detergent or additives
- Low-pH viral inactivation
- Intermediate product pooling between purification steps
- Ultrafiltration/Diafiltration preparation
- Final Formulation/Fill-Finish:
- Excipient and Additive Blending
- Bulk Drug Substance Homogenization
- Adjuvant blending (Vaccines)
The Eberbach Advantage
- Vessel-scale circulation: Eberbach orbital, reciprocal, and rocking shakers generate bulk fluid movement without relying on impeller tips, which only provide localized mixing
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Low shear mixing: By eliminating impeller bags, Eberbach shakers provide:
- Less mechanical stress on sensitive proteins
- Fewer potential collision points
- Lower bubble generation
- Better solids suspension: Eberbach orbital, reciprocal, and rocking shakers suspend and maintain solids more effectively than conventional impeller-driven systems.
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Simpler bag construction: Eliminating internal impellers significantly lowers bag costs while removing multiple operational risks:
- Lower assembly defects and simpler bag manufacturing
- No mechanical failure risks, including impeller seizure and magnetic decoupling
- Elimination of wear points, such as rotational bearing surfaces and fluid-contacting rotating components
- No impeller installation or alignment issues
- Shorter lead times for single-use bag supply
chains
-
No impeller related failure modes: No seizure, no
magnetic decoupling, no bearing wear, no alignment
issues
| 6140 Series - Small Capacity | 6145 Series - Medium Capacity | 6155 Series - Large Capacity |
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Accessories/Options
- Integrated Weighing: Built-in load cell output options for precise measurement.
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Advanced Controls Options: Comprehensive HMI/PLC
control packages featuring audio-visual alarms, recipe
functionalities, and remote diagnostics. -
SCADA & Network Integration Options: Secure user login
controls, remote operation, and robust data extraction
(tracking time, speed, batch ID, and date). -
Specialized Sensors: Application-specific sensor
packages tailored to your exact operational requirements. -
Enhanced Safety: Optional safety enclosures and physical
guarding for maximum operator protection. -
Hazardous Location Rating Options: Explosion-proof
configurations available for sensitive or high-risk environments. - Motion Types: Various mixing motions including orbital, rocker, and reciprocal shaker options.
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Certifications & Labeling: Optional UL 61010 (or equivalent) certifications, CE marking, specialized
material surface finishes, and hazardous/explosion-proof labeling. - CFD Analysis: Optional Computational Fluid Dynamics computer simulations to evalua
Backed by Eberbach Engineering
Every SUM model is constructed for continuous duty operation in demanding lab environments.
Eberbach's engineering team is available to help configure the right setup for your application, including custom designs and specialized configurations through our build request page.